As living drugs, chimeric antigen receptor T-cells (CAR-T cells) come with unique manufacturing and commercialisation challenges. In this respect, the use of fresh leukapheresis material was rapidly recognised as an important bottleneck in...
The efficacy of Tafinlar ® (dabrafenib) + Mekinist ® (trametinib) has been investigated in various studies. Read more below about some important results from these studies.
Adjuvant treatment of stage III melanoma...SOLAR-1:
Pivotal randomized, double-blind, placebo-controlled, multicenter phase 3 trial in HR+/HER2-aBC 1 . A total of 572 patients were enrolled in the trial, including 341 patients with a PIK3CA mutation 1...
Predictable, manageable and reversible side effects while maintaining quality of life 6
As with any medication, side effects may occur when using the combination therapy Tafinlar® (dabrafenib) and Mekinist® (trametinib). The side...
Patients referred for CAR-T therapy have active relapsed/refractory disease and are therefore at high risk of disease progression during the CAR-T manufacturing. In order to prevent clinically significant disease progression during this...
While follicular lymphoma (FL) is an indolent form of non-Hodgkin lymphoma that is generally associated with long remissions, the disease remains incurable and for patients with relapsed/refractory (r/r) FL the prognosis is dismal. The recent...