Mechanism of Action
Kesimpta ® is a targeted and precisely delivered B-cell therapy 1,5
B-cells play a central role in the pathogenesis of MS 4
KESIMPTA ® (ofatumumab) is a fully human anti...
B-cells play a central role in the pathogenesis of MS 4
KESIMPTA ® (ofatumumab) is a fully human anti...
Mechanism of Action (MoA)¹
Iptacopan is a proximal complement inhibitor that targets Factor B (FB) to selectively inhibit the alternative pathway of the complement cascade. Inhibition of FB in the...
Uncontrolled JAK/STAT signalling is characteristic of both polycythaemia vera (PV) 1–5 and for myelofibrosis (MF). 6
JAKs are tyrosine kinases that transmit signals from cytokine or growth factor receptors to the cell...Cosentyx (secukinumab) is a fully human IgG1/κ monoclonal antibody that selectively binds to and neutralizes the proinflammatory cytokine interleukin-17A (IL-17A). 1 Cosentyx works by targeting IL-17A and inhibiting its interaction with...